A "knocking" sound or a "rattle" sound?
I've had rides in non-Mopars that had rod knock. Excessive rod or main bearing clearances have a fairly disticntive sound to each. If it was a damaged bearing, I would think you could have a low oil pressure light issue when fully warmed, at idle in high ambient temps.
While my '93 Grand Caravan w/3.3 V-6 was quiet even with 100,000 miles, our 80,000 mile, '05 Caravan SXT w/3.3 V-6 I now have has more like a "rattle" or "slap" coming from the passenger side (front of the motor).
I'm assume an advantage of having both camshaft and crankshaft position sensors is (also assuming the PCM software supports) the PCM should be able to detect "excessive" chain stretch/wear via an inconsistent cam to crank relationship.
The 1965 Chrysler New Yorker we had with the 413-4BL RB motor at 145,000 miles showed a large variation in ignition timing (degrees of advance). Since it was the original silent type timing chain, I assumed it's chain was pretty loose. I don't remember if the front of that motor was noisey (knock, rattle, etc?) or not.