w250 window seals?
 

So I have an 86 w250 and my passenger side door leaks internally. I want to put nice speakers in it but I don't want them to get wet. I have all the seals for the door and windows. I have the clip on sides to the windows and rubber with window channels that appear to go all the way down the window rail. How should I go about replacing that seal? Does the window need to be completely removed and if so how does it come out? Thanks!