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Yup they'll rub but otherwise it can be done. You may want to do a t/s lift for $50 it will help with the rubbing and if that isn't enough to cream your twinkie do a BL and you shouldn't have any problems and could probably squeeze 33's under there with minor rubbing.
I put a 3" BL and 3"sus lift to fit 34x9.5's on my pathfinder a few years ago, but I didn't want to lift the durango. I decided to just stick with 31's, bought some Dick Cepak FunCountry 2's