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After doing a billion searches I just ordered the diablo intune. From what I've read the predator was good for power and sc was great for trans shifting. The intune website said they have trans settings in it now, where the predator didn't. The intune is the next gen predator and $200 less than the trinity. The ability to correct the speedo to your new tire size will help a lot and most report a few mpg increase with a performance can tune. You can also pay extra for a custom tune once you have the tuner.
If you NEED better gas mileage then DON'T PUT BIGGER TIRES ON YOUR TRUCK! PERIOD. NO TUNER is gonna significantly get you enough fuel economy gains to pay for the tuner itself, let alone make up the difference bigger meats is gonna cost you.