I am looking into upgrading my coils and wires and want to know if there is a difference in going with the two plug coils or sticking with the coil/wire combo?

 

You don't mention your year or engine, but I assume you have the hemi with the long ignition wires that extend across the top of the engine.
If that is your setup, take a look at Taylor shorty wires. I've never heard a complaint about them.

 

it is the 5.7 Hemi in an 05 1500.

 

Basically just cleans up the engine compartment. You can either use the shorties or get pigtail adapters with the 2006-2008 coil packs and valve covers.