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3rd Gen Ram Tech2002-2008 Rams: This section is for TECHNICAL discussions only, that involve the 2002 through 2008 Rams Rams. For any non-tech discussions, please direct your attention to the "General discussion/NON-tech" sub sections.
Not sure about 4500lbs but I just got back from a 400 mile trip and averaged 13.3/mpg pulling 1500 pounds in a stock 08 QC Hemi. I drove nice and easy for the first half there and then not so light on the gas on the return. About 80-90% of driving was with the trailer.
I have about the same setup as you. My boat and trailer go about 4k lbs, on the flat freeway doing about 60 I get about 11 mpg once I get into the hills it goes down to about 9 mpg.