I have a 2012 2500hd 4 door longbed 5.7l h emi with 120k miles. The other day out of nowhere I started to get a misfire in cylinder 7, so I replaced both spark plugs and the coil for that cylinder with no change. Then I swapped injectors 5 and 7 and still no change yet now my 3rd cylinder is misfiring and it is giving me a running lean code. I have no clue what to do or what it could be this is my 1st Dodge and my 1st time messing with a hemi engine any help is greatly appreciated!
Also I have cleared the codes multiple times and they come right back, a shop I used to work at let me use their snap on dialog so I could watch the miss fire sheet and now only cylinder 3 is misfiring. It is still telling me I'm running lean.

 

Check fuel pressure.

 

Interesting that all of the misfires are the odd number cylinders. So the drivers side bank has problems. Not sure how the fuel rails work but look for what ever those cylinders have in common. The cam is one possibility.

 

my pressure is factory spec and all my injectors have the same pulse

 

If fuel pressure is good, but the PCM thinks you are still running lean..... try disconnecting the front O2 sensors, and see if the truck runs any better. (yeah, it's set codes for those.....)

 

I had no idea, I'll try that next thanks