I keep getting the code P0205:injector Circuit/open - cylinder 5

I changed the plugs and wires. What else do I need to do? The check engine light is on as well.

 

Welcome to DF
You can try moving the number 5 injector to another cylinder by switching the injectors. Then ck to see if the injector code went to another cylinder. If it stays the same......... its not the injector, maybe wiring or controller. Or you can just replace the number 5 injector and hope for the best.