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i don't see why it would be problem at all. OK a truck is towing, it may be more weight, but how it is different then a minivan full of adults. the added weight shouldn't hurt it.
Having the overdrive on all the time while towing will cause the trans to shift excessively which in turn can burn up the trans the same goes for going up steep grades you do not want your vehicle in overdrive when the trans is consistently looking for a gear which will and can cause overheating. As for the cruise control I can see the same thing occur as with the overdrive any small incline will cause your vehicle to loose momentum and then we have the same as with overdrive. It would be better to control the speed with your foot.
Not only the exssive shifting but as my dad allways said...If its in the owner Manual not to do it then dont.....By the way its also on the drivers visor....