I have a 1999 ram 1500 cylinders 1-2 have fuel compression and spark but cylinders are dead. new cap rotor and wires plugs have changed injectors and intake gaskets 50 lbs fuel pressure could pcm cause this problem ??

 

Moved to the correct section and changed the title to something resembling your issue. Welcome to DF.

 

Verify the injectors are firing.

What were the compression numbers?

 

injectors firing checks out with noid light compression is 120to 125 across the board

 

Did the parts get changed in hopes to fix this issue, or did it start afterwards?

Ohm out the injectors in question.

You have everything in place there... those cylinders *should* be firing.

 

is there a chance the pcm could cause this problem I've even had injectors out of the manifold and still on the rail and cranked it with the coil disconnected and watched them all spray.

 

If the injector, and plug, are both firing (at the correct time....) then the PCM is doing its job.

 

did the tune up first and it ran great for three to four weeks then these two cylinders went dead

 

Have you rechecked the cap/rotor/wires?

Have you checked for spark AT those cylinders? (end of the plug wire)

Wouldn't hurt to pull the plugs for that test.... and use the plugs from those cylinders to see if anything interesting is happening. (unplug the injector for the cylinder you are testing, to avoid any unwanted occurrences.....)

 

Have you verified that the plugs are firing in the right sequence? Make sure you didn't connect them up in the wrong order.
And make sure you have the injector connectors going to the right injectors.